Evaluating the Risk of Candida albicans Associated with Gestation amongst Women in Port Harcourt, River State, Nigeria

Main Article Content

T. Sampson
A. P. George

Abstract

Candidiasis is increasingly affecting women in developing countries, due to several factors relating to environmental and physiological conditions of the individual. Knowledge of the factors influencing the epidemiology of Candida spp. will be useful in formulating public health measures targeted at reducing the incidence of Candidiasis. This study was therefore conducted to determine the prevalence of Candida albicans amongst women in Port Harcourt, Rivers State, in order to decipher the epidemiology of Candida albicans in relation to age and gestation. A total of seventy (140) vaginal swab samples were collected from 70 pregnant and 70 non-pregnant women in Port Harcourt, and analyzed using standard microbiological methods. The result showed that 36% of the total women studied had Candida albicans while 64% were negative. In the overall analysis, the distribution of the yeast was 43% prevalent in pregnant and 29% in non-pregnant women. The risk of Candidiasis in pregnancy was evaluated using the Odds Ratio (OR) and was determined to be 1.88. Also, a paired sample t-test indicated a positive and strong statistical relationship between age distribution and the presence of Candida albicans in women, with a correlation coefficient of 0.911 (91.1%) (< 0.05), indicating a higher incidence among the older group, albeit lower in age groups close to menopause. The study concluded that the prevalence is higher in pregnant women, with a significant relationship with age. Regular screening of women for Candida spp. should be advocated and women should as well avoid conditions that dispose them to genital tract infections.

Keywords:
Prevalence, Candida albicans, gestation, epidemiology, genital tract infections, odds ratio.

Article Details

How to Cite
Sampson, T., & George, A. P. (2020). Evaluating the Risk of Candida albicans Associated with Gestation amongst Women in Port Harcourt, River State, Nigeria. International Journal of Pathogen Research, 3(3-4), 1-7. https://doi.org/10.9734/ijpr/2019/v3i430098
Section
Original Research Article

References

Das-News K, Horvath LL, Hospenthal DR, Murray CK, Dooley DP. Direct isolation of Candida spp. from blood cultures on chromogenic medium CHROMagar Candida. J. Clin. Microbiol. 2008;41:2629-2632.

Vroumsia T, Moussa D, Bouba G, Daniel EM, Ebot KC, Eneke T, Vikumitsi VA, Thomas N. Prevalence of Vulvovaginal Candidiasis amongst pregnant women in Maroua (Cameroon) and the sensitivity of Candida albicans to extracts of six locally used antifungal plants. International Research Journal of Microbiology (IRJM). 2013;4(3):89-97.

Dou N, Li W, Zhao E, Wang C, Xiao Z, Zhou H. Risk factors for candida infection of the genital tract in the tropics. Afr Health Sci. 2014;14(4):835–839.

Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes GMJS. Candida species: Current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. Journal of Medical Microbiology. 2013;62:10–24.

Ibrahim SM, Bukar M, Mohammed Y, Audu BM, Ibrahim HM. Prevalence of vaginal Candidiasis among pregnant women with abnormal vaginal discharge in Maiduguri. Niger J. Med. 2013;22:138‑42.

Uwamahoro O, Traven R. Antifungal resistance among Candida species from patients with genitourinary tract infection isolated in Benin City, Edo Estate, Nigeria. Afr J. Microbiol Res. 2009;3(11):694–699.

Anthony UE, Idris AN, Justus O, Alinwachukwu LI. Prevalence of vulvovaginal candidiasis among nonpregnant women attending a tertiary health care facility in Abuja, Nigeria. Research and Reports in Tropical Medicine. 2015;6:37–42.

Sobel JD, Faro S, Force RW, Fox B. Vulvovaginal candidiasis; epidemiologic, diagnostic and therapeutic considerations. Am J. Obstet Gynaecol. 1998;178:203‑11.

Okonkwo NJ. Prevalence of vaginal candidiasis among pregnant women in Nnewi Town of Anambra State, Nigeria. International Multi-Disciplinary Journal, Ethiopia. 2010;4(4):539-548.

Jindal N, Gill P, Aggaarwal A. An epidemiological study of vulvovaginal candidiasis in women of childbearing age. Indian J. Med Microbiol. 2007;25:175‑6.

Deorukhkar SC, Saini S, Mathew S. Non-albicans Candida infection: An emerging threat. Interdisciplinary Perspectives on Infectious Diseases. 2014;1.

Donbraye-Emmanuel OOB, Donbraye E, Okonko IO. Detection and prevalence of Candida among pregnant women in Ibadan, Nigeria. World Applied Sciences Journal. 2010;10(9):986-991.

CDC. Sexually transmitted diseases treatment guidelines; 2015.
Available:https://www.cdc.gov/std/tg2015/candidiasis.htm

Nnadi DC, Singh S. The prevalence of genital Candida species among pregnant women attending antenatal clinic in a tertiary health center in North-west Nigeria. Sahel Med J. 2017;20:33-7.

Akinbiyi AA, Watson R, Feyi-Waboso P. Prevalence of Candida albicans and bacterial vaginosis in asymptomatic pregnant women in South Yorkshire, United Kingdom. Arch. Gynecol Obstet. 2008;278:463-466.

Uzoh CV, Iheukwumere IH, Umezurike KC, Onyewendo SC. Prevalence of Candida albicans among women attending Federal Medical Centre Asaba, South-South, Nigeria. Journal of Advances in Life Science and Technology. 2016;41:54-58.

Martins N, Ferreira ICFR, Barros L, Silva S, Henriques M. Candidiasis: Predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014;177(5-6):223-40.

Nwadioha SI, Egah DZ, Alao OO, Iheanacho E. Risk factors for vaginal candidiasis among women attending Primary Health Care Centres of Jos, Nigeria. J Clin Med Res. 2010;2:110‑3.

Nwosu CA, Djieyep NA. Candidiasis and Trichomoniasis among pregnant women in the Semi-Arid Zone, North‑Eastern Nigeria. West Afr J Med. 2007;26:17‑9.

Pfaller MA, Diekema DJ. Role of sentinel surveillance of candidemia: Trends in species distribution and antifungal susceptibility. J Clin Microbiol. 2002;40(10):3551–3557.

García HM, García SD, Copolillo EF, Cora EM, Barata AD, Vay CA, de Torres RA, Tiraboschi N, Famiglietti AMR. Prevalence of vaginal candidiasis in pregnant women. Identification of yeasts and susceptibility to antifungal agents. Revista Argentina de Microbiología. 2006;38(1):9-12.