An Overview of COVID-19 Vaccines: Challenges of the Discovery and Development by the Pharmaceutical Industries
International Journal of Pathogen Research, Volume 11, Issue 3-4,
Page 13-31
DOI:
10.9734/ijpr/2022/v11i2209
Abstract
The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization and action towards vaccines and drug repurposing. This pandemic triggered an emergence therapy intervention of which the development of new vaccine and drug repurposing were good options that was to be validated by regulatory authorities for potential use for enhancing acquired immunity for the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Prior to the outbreak that led to the global health emergency intervention, an understanding of the viral architecture, pathophysiology and mechanism of action and functions were well established. The global health disaster caused by COVID-19 has generated significant interest globally for research in vaccine discovery and development by many research institutions and Pharmaceutical sectors since 2019. So far, the approval of many clinical trials tested vaccines by the regulatory authorities have led to the need for post approval concerns of efficacy, safety and quality of these approved vaccines. This review paper attempts to explore the vaccines approved for global access to the population discovery and development process, the potential safety implications. An insight into other therapy options such as the convalescence plasma treatment and management for the global COVID-19 pandemic has been reviewed.
- Coronavirus
- COVID-19
- vaccine
- SARS-COV-2
- immunity
- China
How to Cite
References
Zheng C, Shao W, Chen X, Zhang B, Wang G. Zheng C, Shao W. Real-world effectiveness of COVID-19 effectiveness of COVID-19 a literature review and meta-analysis. Int J Infect Dis. 2022;114:252-260.
DOI: 10.1016/j.ijid.2021.11.009
Nikolopoulou GB, Maltezou HC. Covid-19 in children: Where do we stand? Arch Med Res. 2022;53(1):1-8.
DOI: 10.1016/j.arcmed.2021.07.002
Chen Y, Xu Z, Wang P, Li XM, Shuai ZW, Ye DQ, Pan HF. New-onset autoimmune phenomenon post-COVID-19 vaccination. Immunology. 2022;165(4):386-401.
DOI: 10.1111/imm.13443
Feikin DR, Higdon MM, Abu-Raddad LJ, Andrews N, Araos R, Goldberg Y, Groome MJ, Huppert A, O’Brien KL, Smith PG, Wilder-Smith A, Zeger S, Deloria Knoll M, Patel MK. Duration of effectiveness of vaccine against SARS-CoV-2 infection and COVID-19 disease results of a systematic review and meta-regression. Lancet. 2022;399(10328):924-944.
DOI: 10.1016/S0140-6736(22)00152-0
Fu W, Sivajohan B, McClymont E, Albert A, Elwood C, Ogilvie G, Money D. Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants. Int J Gynaecol Obstet. 2022;156(3):406-417.
DOI: 10.1002/ijgo.14008
Available:http://www.gavi.org/covid-19/vaccines
last access 2 October, 2022.
Available:https://www.who.int/covid-19/vaccines-COVID-19
vaccine updates-World Health Organization.
Available:https://www.disasterphilanthropy.org
Covid-19 disaster profile-get the latest on covid-19.
Elizabeth B Pathak. "Convalescent plasma is ineffective for covid-19". BMJ; 2020.
Available:http://www.thailandmedical.news, Access on 2 October, 2022.
Nerina Boschiero N. "COVID-19 vaccines as global common goods: An integrated approach of ethical, economic policy and intellectual property management". Global Jurist; 2022.
Niebel D, Novak N, Wilhelmi J, Ziob J, Wilsmann-Theis D, Bieber T, Wenzel J, Braegelmann C. Cutaneous adverse reactions to COVID-19 vaccines: Insights from an immuno-dermatological perspective. Vaccines (Basel). 2021;9(9): 944.
DOI:10.3390/vaccines9090944
Accorsi EK, Britton A, Fleming-Dutra KE, Smith ZR, Shang N, Derado G, Miller J, Schrag SJ, Verani JR. Association between 3 doses of mRNA COVID-19 vaccine and symptomatic infection caused by the SARS-Cov-2 Omicron and Delta variants. JAMA. 2022;327(7):639-651.
DOI: 10.1001/jama.2022.0470.PMID:35060999
Gröber U, Holick MF. The coronavirus disease (COVID-19). A supportive approach with selected micronutrients. Int. J. Vitam Nutr. Res. 2022;92(1):13-34.
DOI: 10.1024/0300-9831/a000693
Peeling RW, Heymann DL, Teo YY, Garcia PJ. Diagnostics for COVID-19: Moving from pandemic response to control. Lancet. 2022;399(10326):757-768.
DOI: 10.1016/S0140-6736(21)02346-1
Lee ACK, Morling JR. COVID-19 vaccine dilemmas. Public Health. 2022; 202:10-11.
DOI: 10.1016/j.puhe.2021.01.009
Tembe-Fokunang EA, Awah KP, Banin AN, Dobgima JF, Nubia KC, Fokam J, Fokunang BL, Enoluomen EB, Igweze ZN, Duerr R, Ondoua MTA, Tiskoff S, Fokunang. Medical anthropology, artificial intelligence and gain of function research perspective in the management of covid-19 pandemic in sub-Saharan Africa. Eur.J. Pharmaceut. Med, Res. 2021;8(11):76-90. SJIF Impact Factor 6.222.
Dobgima JF, Tembe EF, Ngwasiri PN, Noumo TN, Njinkio NB, Fokunang LB, Edrice AES, Bengyella Louis Tita BL, Kaba CN, Ejoh RA, Tita M, Fokunang CN. Nutritional management approach for possible prevention of covid-19 infection and transmission in sub-saharan and biodiversity endowed countries. Journal of Complementary and Alternative Medical Research. 2021;33(22):39-58.
DOI: 10.9734/JAMMR/2021/v33i2231158
Wibawa T. COVID-19 vaccine research and development ethical issues. Trop Med Int Health. 2021;26(1):14-19.
DOI: 10.1111/tmi.13503
Ita K. Coronavirus Disease (COVID-19): Current status and prospects for drug and vaccine development. Arch Med Res. 2021;52(1):15-24.
DOI: 10.1016/j.arcmed.2020.09.010
Franchini M, Liumbruno GM, Pezzo M. COVID-19 Vaccine-associated Immune Thrombosis and Thrombocytopenia (VITT). Diagnosis and therapeutic recommendations for a new syndrome. Eur J Haematol. 2021;107(2):173-180.
DOI: 10.1111/ejh.13665
Lamb YN. BNT162b2 mRNA COVID-19 vaccine: First approval. Drugs. 2021;81(4): 495-501.
DOI: 10.1007/s40265-021-01480-7
Li YD, Chi WY, Su JH, Ferrall L, Hung CF, Wu TC. Coronavirus vaccine development; from SARS and MERS to COVID-19. J Biomed Sci. 2020;27(1):104.
DOI: 10.1186/s12929-020-00695-2.
Soleimanpour S, Yaghoubi A. COVID-19 vaccine: where are we now and where should we go? Expert Rev vaccine. 2021;20(1):23-44.
DOI: 10.1080/14760584.2021.1875824.
Salah HM, Mehta JL. COVID-19 vaccine and myocarditis. Am J Cardiol. 2021;157: 146-148.
DOI: 10.1016/j.amjcard.2021.07.009
Hodgson SH, Mansatta K, Mallett G, Harris V, Emary KRW, Pollard AJ. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect Dis. 2021;21(2):e26-e35.
DOI: 10.1016/S1473-3099(20)30773-8
Kamidani S, Rostad CA, Anderson EJ. COVID-19 vaccine development a pediatric perspective. Curr Opin Pediatr. 2021;33(1):144-151.
DOI: 10.1097/MOP.0000000000000978.
Greinacher A, Thiele T, Theodore E, Weisser KK, Paul A, Eichinger S. Thrombotic thrombocytopenia after CHAdOX1 nCov-19 vaccination. New England Journal of Medicine: NEJ Moa.2104840 (9 April 2021).
DOI:10.1056/NEJMoa2104840
Niebel D, Novak N, Wilhelmi J, Ziob J, Wilsmann-Theis D, Bieber T, Wenzel J, Braegelmann C. Cutaneous adverse reactions to COVID-19 vaccines: Insights from an immuno-dermatological perspective. Vaccines (Basel). 2021;9(9): 944.
DOI:10.3390/vaccines9090944
Cines DB, Bussel T, James B. SARS-CoV-2. vaccine-induced immune thrombotic. Thrombocytopenia. New England Journal of Medicine, 16, 2021: NEJMe2106315.
Doi:10.1056/NEJMMe216315
Astra Zeneca COVID-19 vaccine (AZD1222) (PDF)> ACIP COVID-19. Emergency Meeting. AstraZeneca, 27 January 2021. Access on 05 November 2021.
Covid-19 vaccine safety update: VAXZEVRIA (PDF). European Medicines Agency. 28 March 2021 Access on 11 Oct 2021.
Johnsen COVID-19 vaccine {Ad26.COV@. S recombinant product monograph (PDF). 5 March 2021. Access on 28 August, 2021.
Marks Peter. Joint CDC and FDA statement on Johnson and Johnson COVID-19.
Access on 20 Oct 202.
Valeriani ER, Nicoletta NM, Marcello DA, Walter R. Splanchnic vein thrombosis. Current perspective. Vascular health and Risk Management. 2019; 15:449-461.
DOI:10.2147/VHRM.S197732
Greinacher A, Selleng K, Warkentin TE. Autoimmune heparin-induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 2017;15(11):2099-2114.
DOI:10.1111/jth.13813
GACVS. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca.COVID-19 vaccine. World Health Organization 19 March, 2021, Aeccess on 23 October, 2021.
Li YD, Chi WY, Su JH, Ferrall L, Hung CF, Wu TC. Coronavirus vaccine development: from SARS and MERS to COVID-19. Journal of Biomedical Science. 2020;27(1):104.
DOI: 10.1186/s12929-020-00695-2, PMC 7749790
Mullard A. How COVID vaccines are being divvied up around the world Canada leads the pack in terms of doses secured per capita. Nature.
DOI: 10.1038/d41586-020-03370-6
So AD, Woo J. Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis. BMJ, 2020;371:m4750.
DOI: 10.1136/bmj.m4750
Gao W, Tamin A, Soloff A, D'Aiuto L, Nwanegbo E, Robbins PD, et al. Effects of SARS-associated coronavirus vaccine in monkeys. Lancet. 2003;362(9399):1895–96.
DOI:10.1016/S0140-673(03)14962-8
Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD, Coccia JA, et al. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immune prophylaxis in mice. The Journal of Infectious Diseases. 2005; 191(4):507–14.
DOI:10.1086/427242
Roberts A, Thomas WD, Guarner J, Lamirande EW, Babcock GJ, Greenough TC, et al. Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters. The Journal of Infectious Diseases. 2006;193(5):685–92.
DOI:10.1086/500143
SARS (Severe Acute Respiratory Syndrome. National health service. 5 March 2020. Archived from the original on 9 March, 2020. Access on 31 January 2020.
Shehata MM, Gomaa MR, Ali MA, Kayali G. Middle East respiratory syndrome coronavirus: A comprehensive review. Frontiers of Medicine. 2016;10(2):120–36.
DOI:10.1007/s11684-016-0430-6, PMC 708926
Yong CY, Ong HK, Yeap SK, Ho KL, Tan WS. Recent advances in the Vaccine Development against Middle East respiratory syndrome-coronavirus. Frontiers in Microbiology. 2019;10:1781.
DOI:10: 3389/fmicb.2019.01781, PMC 6688523
Le TT, Cramer JP, Chen R, Mayhew S. Evolution of the COVID-19 vaccine development landscape. Nature Reviews Drug Discovery. 2020;19(10): 667–68.
DOI:10.1038/d41573-020-00151-8
Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M, et al. The COVID-19 vaccine development landscape. Nature Reviews Drug Discovery. 2020;19(5):305–06.
DOI:10.1038/d41573-020-00073-5
Simpson S, Kaufmann MC, Glozman V, Chakrabarti A. Disease X: Accelerating the development of medical counter measures for the next pandemic. The Lancet. Infectious Diseases. 2020;20(5): e108–15.
DOI:10.1016/S1473-3099(20) 30123-7
Wee S. China’s coronavirus vaccine drive empowers a troubled industry. The New York Times; 2020. ISSN 036-4331. Archived from the original on 4 May, 2020. Access on 4 May 2020.
Thorp HH. Under promise, Overdeliver. Science. 2020;367(6485):1405. Bibcode: 2020Sci. 367.1405T.
DOI: 10.1126/science. abb8492
Blackwell T. COVID-19 vaccine researchers say pandemic lockdown placing many serious obstacles to their work. national post, 2020; Archive from the original on 1 November 2020. Access on 3 May, 2020.
The drug development process. US Food and Drug Administration (FDA). 4 January 2018. Archived from the original on 22 February 2020. Access on 12 April 2020.
Dubé E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger J Vaccine hesitancy: An overview. human vaccines and immunotherapeutics, 2013;9(8):1763-1773.
DOI:10.4161/hv.24657
Abedi M (23 March 2020). "Canada to spend $192M on developing COVID-19 vaccine". Global News. Archived from the original on 9 April 2020. Access on 24 March 2020.
Takada N, Satake M. US and China unleash wallets in race for coronavirus vaccine. Nikkei Asian Review, 2020. Archived from the original on 10 May 2020. Access on 3 May 2020.
World Health Organization timeline. World Health Organization. 27 April 2020. Archived from the original on 29 2020. Aeccess on 2 May 2020.
Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M, et al. The COVID-19 vaccine development landscape. Nature Review Drug Discovery. 2020;19(5).
DOI:10.1038/d41573-020-00073-5. ISSN 1474-1776.
Gates B. Responding to COVID-19: A once in a century pandemic? The New Englang Journal of Medicine. 2020;382(18):1677-1779.
DOI:10.1056/nejmp 2003762
Fauci AS, Lane HC, Redfield RR. COVID-19: Navigating the uncharted. The New England Journal of Medicine. 2020; 382(13):1268-1269.
DOI:101056/nejme2002387. PMC71211221
Cramer JP, Chen R, Mayhew S. Evolution of the COVID-19 vaccine development landscape. Nature Re. view Drug Discovery. 2020:19(10):667-668.
DOI:1038/d41573-020-00151-8. ISSN:01474-1776.
Ahmed DD. Oxford, AstraZeneca COVID-19 deal reinforces vaccine soverignty2020, Sata. Archived from the original on the 12 June 2020. Access on 8 June 2020.
WHO backed China’s emergency use of experimental COVID-19 vaccine. South China Morning Post. 25 September 2020. Archived from the original on 26 September 2020. Retrieve 26 September 2020.
Kramer AE. Russia is slow to administer virus vaccine despite Kremlin’s approval. The New York Times. 2020. ISSN 0362-4331. Archived from the original on 27 September. Access on 28 September, 2020.
Pfizer and BioNTech to submit emergency use authorization request. Today to the USA FDA for COVID-19 vaccine. Pfizer press release 20 November 2020, Access on 20 November, 2020.
Park A. Exclusive Pfizer CEO Discusses submitting the firs COVID-19 vaccine. Clearance Request to the FDA. Time, 2020. Access on 20 November, 2020.
Thomas K, LaFraniere S, Weiland N, Goodnough A, Haberman M. FDA clears Pfizer vaccine, and millions of doses will be shipped right away. The New York Times; Access on 12 December, 2020
Classification of omicron (B.1.1.529): SARS-CoV-2 variants of concern. WHO. 26 November 2021. Access on 26 Nov, 2021.
Parekh M, Platt P.Team. Global Health Security. Coronavirus latest news: EU suspends all flights to Southern Africa over omicron COVID variant fears. The Telegraph 2021, ISSN0307-1235. Archived from the original on the 26 November 2021. Access on 26 November 2021.
Meyer D, David. What’s Omicron? Here’s what we know and don’t know about the new COVID variant that’s roiling market and air travel. Fortune, 2021. Archived from the original on 26 November 2021. Access on 26 November 2021.
Torjesen I. Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientist fear, BMJ. 2021;375: n2943.
DOI:10.1136/bmj. n2943.ISSN1756-1833.
Patel V, Vimal Hoe. Omicron, the new Covid-19 variant, got its name. The New York Times, 2021. ISSN0362-4331Archived from the original on 28 November 2021. Access on 28 November 2021.
What do you need to know about Omicron? Biden says be concerned, but don’t panic, NPR, 2021, Access on Nov 2021.
FDA takes additional action in fight against COVID-19, by issuing emergency use authorization for second COVID-19 vaccine. US Food & Drug Administration (FDA) press release. Retrieved 18 December 2020.
Oliver SE, Gargano JW, Marin M, Wallace M, Curran KG, Chamberland M, et al. The advisory Committee on Immunization Practices. Interim Recommendation for use of Moderna COVID-19 Vaccine, United States, Dec 2020. MMWR Morbidity and Mortality Weekly Report, 2020;69(5152): 1653–1656.
DOI:10.15585/mmwr.mm695152el.
Park KS, Sun X, Aikins ME, Moon JJ> Non-viral COVID-19 vaccine delivery systems. Advanced Drug Delivery Reviews; 2020; 169:137–51.
DOI: 10.1016/j.addr.2020.12.008.
Kowalski PS, Rudra A, Miao L, Anderson DG. Delivering the Messenger. Advances in Technologies for Therapeutic mRNA. Delivery. Mol Ther, 2019;27(4):710–28.
DOI: 10.1016/j.ymthe.2019.02.012.
Verbeke R, Lentacker I, De Smedt SC, Dewitte H. Three decades of mRNA vaccine development. Nano.Today; 2019; 28:100766.
DOI: 10.1016/j.nantod.2019.100766.
Palca J. COVID-19 vaccine candidate heads to widespread testing in US. NPR; 2020. Archived from original on 11 October 2020. Access on 27 July 2020.
Johnson C, McGinley L. Johnson & Johnson seeks emergency FDA authorization for single shot coronavirus vaccine. The Washington Post; 2020.
Farge, Emma, Revill, John. WHO recommends two doses of Pfizer COVID-19 vaccine within 21-28 days. Reuters, Geneva, 2021. Access on 2021.
Keaten J, WHO: Amid short supplies, vaccine does can be 6 weeks apart. Associated Press; 2021. Geneva. Access on 6 March 2021.
Jones I, Roy P, Polly. Sputnik V Covid-19 vaccine candidate appears safe and effective. The Lancet. 2021;397(10275): 642–643.
DOI:10.1016/s0140-6736(21)00191-4. PMC7906719.
Logunov DY, Dolzhikova IV, Shcheblyakov DV, Tukhvatulin AI, Zubkova OV, Dzharullaeva AS, et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19: Vaccine: An interim analysis of a randomized controlled phase 3 trial in Russia. The Lancet. 2021;397(10275): 671–681.
DOI:10.1016/S0140-6732(21)00234-8. ISSN-0140-6736. PMC7852454.
Walsh N, Shelley J, Duwe E, Bonnett W.The world’s hopes for a coronavirus vaccine may run in these health care workers’ vein. São Paulo: CNN, 2020; Archived from the original on 3 August 2020. Access on 3 August 2020.
Gallagher J, Triggle N. COVID-19: Oxford-AstraZeneca vaccine approved for use in UK. BBC; 2020. Access on 5 March 2020.
AstraZeneca. COVID-19 vaccine (PDF) (Product Monograph). AstraZeneca; 2020., 2020. 26 February 2021. 244627. Access on 5 March 2021.
Voysey M, Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, et al. Single-dose administration and the timing of the booster dose on immunogenicity and efficacy of ChAOx1 nCoV-19. (AZD1222): A pooled analysis of four randomized trials. The Lancet. 2020;397(10277):881-891.
DOI:10.1016/S0140-6736(21)00432-3. Access on 10 March 2021.
Xia S, Zhang Y, Wang Y, Wang HY, Yunkai GG et al. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomized, double-blind, placebo-controlled, phase1/2 trial.The Lancet Infectious Diseases. 2020;21(1):39–51.
DOI:10.1016/S1473-3099(20)30831-8. PMC7561304.
Elbahrawy F, Lyu D, Omar A, Che C, Paton J. China State-Backed Covid vaccine has 86% efficacy, UAE says. Bloomberg News; 2020. Access on 5 March 2020.
Wee S, Qin A. A Chinese Covid-19 vaccine has proved effective, its makers says. The New York Times; 2020. Access on 30 December 2020.
Yang Y. A study to evaluate the efficacy, safety and immunogenicity of inactivated SARS-CoV-2 vaccines (Vero cell) in healthy population aged 18 years and above. Clinicaltrials.gov. Archived from the original on 14 September 2020. Access on 15 Sept 2020.
Bahrain allows Sinopharm COVID-19 vaccine candidate use in frontline workers. MSN. Reuters; 2020, Access on 3 November 2020.
Tan Y. Covid: What about China’s coronavirus vaccines? BBC; 2020. Access on 5 March 2020.
Soeriaatmadja W. Indonesia grants emergency use approval to Sinovac’s vaccine, local trials show 65% efficacy. The Staits Times; 2021. Access on 11 January, 2021.
Sinovac: Brazil results show Chinese vaccine 50.4% effective. BBC New; 2021. Aeccess on 12 February 2021.
Baden L, Essink B, Kotloff K, Frey S, Novak R, Diemert D, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine. 2020;384(5):403–416.
DOI:10.1056/NEJMoa2035389.PMC7787219.
Jansen Ad. COV2. S Vaccine for prevention of COVID-19 (Briefing). FDA; 2021:6. Access on 6 March 2021.
Ledford H. J&J’s one shot COVID vaccine offers hope for faster protection. Nature; 2021.
DOI:10.1038/d41586-021-00119-7. PMID 33526898.
Johson & Johnson announces single-shot JanssenCOVID-19 vaccine candidate Met Primary Endpoint in Interim Analysis of its Phase 3 ENSEMBLE Trial (Press Release). Johnson & Johnson; 2021. Access on 29 January 2021.
Janssen COVID-19 Vaccine-ad26cov2.s injection suspension. DailyMed. US National Institute of Health. Retrieved 15 March2021.
Zhu FC, Guan XH, Li YH, Huang JY, Jiang T, Hou LH, et al. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years old or older: a randomized, double-controlled, phase 2 trail. Lancet. 2020;396(10249):479–88.
DOI:10.1016/s0140-6736(20)31605-6. ISSN0140-6736. PMC7836858.
Peshimam G, Farooq U. CanSinoBIO’s COVID-19 vaccine 65.7% effective in global trials. Pakistan official says. Reuters Islamabad, 2021. Access on 5 March 2021.
Ng E China’s CanSino trials Covid-19 vaccine in high disease burden’ nations. South China Morning Post; 2020. Access on 4 November 2020.
Gou J. Phase III Trial of a COVID-19 Vaccine of Adenovirus vectors in adults 18 years old and above. ClinicalTrial.gov. Archived from the original on 18 September 2020. Access on 17 September 2020.
Ryumin A. Russian registers its third COVID-19 vaccine COviVac. TASS. Moscow; 2021.
Access on 6 March 2021.
Rojas M, Rodríguez Y, Monsalve DM, et al. Convalescent plasma in Covid-19: Possible mechanisms of action. Autoimmun Rev. 2020; 19:102554.
Doi: 10.1016/j.autrev.2020.102554 pmid:32380316.
Subbarao K, Mordant F, Rudraraju R. Convalescent plasma treatment for COVID-19: Tempering expectations with the influenza experience. EurJImmunol. 2020; 50:1447-53.
DOI: 10.1002/eji.202048723 pmid: 32886952.
Piechotta V, Chai KL, Valk SJ, etal. Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review. Cochrane Database Syst Rev. 2020;7: CD013600.pmid: 32648959.
Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P. The PLACID Trial Collaborators. Convalescent plasma in the management of moderate COVID-19 in India: An open-label parallel-arm phase II multi-centre randomized controlled trial (PLACID Trial). BMJ. 2020; m3939.
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020; 324:782-93.
DOI: 10.1001/jama.2020.12839 pmid: 32648899.
Estcourt LJ, Roberts DJ. Convalescent plasma for covid-19. BMJ. 2020;370:m3516.
DOI: 10.1136/bmj.m3516 pmid: 32933945.
Lapid N. Common cold antibiotics hold due to COVID-19 behaviors, lung scans speed COVID-19 diagnosis in stroke patients. Healthcare Pharmac, Nov 2020 at 7.46PM.
NIH. Scientist discover key pathways in lysosomes that coronavirus use to exit cells. Biology and Microbiology; 2020.
Sourish G, Teegan A, Dellibovi R, Kervil A et al. B coronavirus uses lysosomes from egress instead of the biosynthetic secretary pathway. Biology & Microbiology; 2020.
DOI: https??doi.org??10.1016/j.cell.2020.10.039.
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