Association of Proteobacteria and Bacteriodetes with Obese Related Type-2 Diabetes Mellitus
International Journal of Pathogen Research, Volume 12, Issue 1,
Page 38-44
DOI:
10.9734/ijpr/2023/v12i1219
Abstract
Background: Metabolic conditions such as Type2 diabetes mellitus (T2DM) and obesity have become worldwide public health important. Numerous evidences indicate that gut Proteobacteria and Bacteriodetes are associated with these co-morbidities. Thus, the gut microbiota serves as a promising target for prognosis of metabolic disorders. The aim of this study is to evaluate the role of gut Proteobacteria and Bacteriodetes on obese related Type 2 diabetes mellitus. The gut microbiota signature of 10 adults was studied using 16S rRNA sequencing targeting V3–V4 hypervariable regions and obtained data was analyzed using Statistical Package for the Social Science (SPSS version 26). Result: The Pearson correlation analysis showed that phyla Bacteriodetes was significant positive when correlated with Body mass index (BMI) (r = 0.666, p = 0.002*), followed by phyla proteobacteria (r = 0.464, p = 0.045*), Firmicutes versus BMI (p>0.05), Actinobacteria versus BMI (p>0.05), while Firmicutes versus Glycated hemoglobin(HbA1c) (p>0.05), Bacteriodetes versus HbA1c (p>0.05), Proteobacteria versus HbA1c (p>0.05), Actinobacteria versus HbA1c (p> 0.05). Conclusion: The study revealed the abundance of phyla Proteobacteria and phyla Bacteriodetes were significantly associated with obese related type 2 diabetes mellitus. Although, these Phyla/ taxa showed no significant correlation with Hb1Ac in obese related type 2 diabetes mellitus.
- Type2 diabetes
- obese
- Proteobacteria
- Bacteriodetes
- glycated hemoglobin
- body mass index
How to Cite
References
Vaibhav S, Amit V, Arsha LMJ. Akshita K, Nirmegh B. Curr Microbiol. Phylogenomics of the Phylum proteobacteria: Resolving the Complex Relationships. 2022; 79(8)224.
Kersters K, De Vos P, Gillis M, Swings J, Vandamme P, Stackebrandt E. Introduction to the Proteobacteria. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E, editors. The prokaryotes. New York: Springer; 2006.
Lambeth SM, Carson T, Lowe J, Ramaraj T, Leff JW, Luo L, et al. Composition, diversity and abundance of gut microbiome in prediabetes and Type 2 diabetes. J Diabetes Obes. 2015;2(3):1-7.
Oshim IO, Agbakoba RN, Oguejiofor CO, Anukam KC. Gut microbiota Compositions and Modulation of Bacterial Metabolic Functional Genes in Type −2 diabetes mellitus individuals at Nnewi, Anambra State, Nigeria. J Adv Med Pharm Sci. 2020;30(3):136-50.
Mukhopadhya I, Hansen R, El-Omar EM, Hold GL. IBD-what role do proteobacteria play? Nat Rev Gastroenterol Hepatol. 2012;9(4):219-30.
Satokari R. High intake of sugar and the balance between pro- and anti-inflammatory gut bacteria. Nutrients. 2020; 12(5):1348.
Satokari R. Contentious host-microbiota relationship in inflammatory bowel disease can foes become friends again? Scand J Gastroenterol. 2015;50(1):34-42.
Hiippala K, Kainulainen V, Suutarinen M, Heini T, Bowers JR, Jasso-Selles D et al. Isolation of anti-inflammatory and epithelium reinforcing Bacteroides and Parabacteroides spp. from a healthy fecal donor. Nutrients. 2020;12(4):935.
Johnson EL, Heaver SL, William AW, Ruth EL. Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes; 2016.
Thomas F, Hehemann JH, Rebuffet E, Czjzek M, Michel G. Environmental and gut Bacteroidetes: the food connection. Front Microbiol. 2011;2:93.
Wexler HM. Bacteroides: The Good, the Bad, and the Nitty-Gritty. Clin Microbiol Rev. 2007;20(4):593-621.
Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh et al. Global patterns of 16S rRNA diversity at a depth of millions of Sequences per sample. Proc Natl Acad Sci U S A. 2011;45:16-22.
Zhang X, Shen D, Fang Z, Jie Z, Qiu X, Zhang C et al. Human gut microbiota changes reveal the progression of glucose intolerance. Plos One. 2013;8(8):e71108.
Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA. 2009; 106(7):2365-70.
Sun L, Yu Z, Ye X, Zou S, Li H, Yu D et al. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care. 2010;33(9):1925-32.
-
Abstract View: 11 times
PDF Download: 8 times
