Molecular Signature of Human Papillomavirus in Upper Aerodigestive Tract Cancers in Congo-Brazzaville
International Journal of Pathogen Research,
Introduction: Carcinomas of the upper aerodigestive tract have a tropism on the epidermoid mucosa. HPV infection remains one of the risk factors for this cancer. This work aimed to study the presence of human papillomavirus (HPV) in carcinomas of the VADS.
Materials and Methods: This was a cross-sectional descriptive and analytical study with retrospective data collection over 7 years. The molecular analysis was conducted in Pointe-Noire using Xpert® HPV technology (GeneXpert, Cepheid). The variables studied were anatomopathological and virological.
Results: The overall molecular prevalence of oncogenic HPV was 28.1%. HPV-16 and HPV-18/45 were the incriminating genotypes in 88.9% and 11.4% of cases, respectively. A statistically significant association was found between co-infection with HPV-oncogenes in subjects over 40 years of age (P=0.01) and the development of these HPVs in squamous cell carcinomas (p=0.02). Notably, oncogenic HPV was found in the majority of laryngeal carcinomas.
Conclusion: In countries with limited resources, the Xpert HPV technology from GéneXpert is a reliable and rapid solution for the virological diagnosis of oncogenic HPV associated with carcinomas of the VADS. HPV-16 remains the most prevalent genotype.
- Xpert HPV
- Géne Xpert
How to Cite
2. Parkin DM, Bray F, et al. The burden of HPV related cancers vaccine. 2006;24:11-25.
3. Louie K, Didelot M, et al. Human papillomavirus and associated cancers: Epidemiological aspect: Revue Francophone des laboratories. 2008;27-34.
4. Hantz S, Alain S, et al. Diagnosis of papillomavirus infections: State of play and perceptive, Therapeutic medicine / pediatrics. 2010;13:20-32.
5. Sellors JW, Karwalajtys TL, et al. Incidence, clearance and predictors of human papillomavirus infection in women CMAJ. 2003;168:421-425.
6. Westa, WH. Detection of human papillomavirus (HPV), in clinical samples: evolving methods and strategies of the accurate determination of HPV status and neck carcinoma, oral oncol. 2014;50:771-9.
7. Otouana Dzon B, Ngouoni GC, Diembi S, Ondzotto GW, Itiere Odzili FA. HPV positive laryngeal carcinoma: epidemiological, virological and progressive features otolaryngol online. 2020;10(4):1-4.
8. Prades JM, Reyt E. Cancer of the larynx: EMC otolaryngology. 2016;8(2):1-15.
9. Luc Z, Li Y, Xu N. Infection and integration status of high-risk human papilloma virus 16/18 in laryngeal cancer. The Journal of Practical Medicine. 2016;32:1422-14.
10. Zhang Y, Chen X, Li X. Correlation of positive expressions of HPV and EPSTEIN AFB virus (EBV) with carcinoma of the larynx. The Journal of Practical Medicine. 2017;33:2117-22.
11. Tong F, Geng Yan B. Prevalence and prognostic importance of HPV in squamous cell carcinoma of the larynx in northeast China. Cell physiol Biochene. 2018;49:206-16.
12. Dayyni F, Etzel CJ, Lin M, et al. Meta analysis of the impact of human papillomavirus (HPV) on cancer visk, overall survival in head, neck squamous cell carcinomas (HNSCC) head neck oncol; 2016;2:15.
13. Si Mohamed.A, Badoual.C, Hans.S et al An unusual human papillomavirus type 82 detection in laryngeal squamous cell carcinomas case report and review of litteratue.J Clin Virol. 2017;54: 190-3
14. Kreimer.AR, CliffordGM, Boyle.P, Franceschi.S, Human papillomavirus types in head and neck squamous cell carcinomas world wide: A systematic review. Cancer Epidemiol Boimarkers Prev 2018;14:467-75.
15. Gillison .ML, Broutain.T, PickardRK, et al Prevalence of oral HPV infection in the united states, 2009-2010, JAMA. 2017;307:693-703.
16. Chernock RD, LewisJS JR, Rhang.Q, Eql MoftySK, Human papillomavirus positive basaloid squamous cell carcinomas of the upper aerodigestive tract: A district clinico Pathology and molecular subtype of basaloid squamous cell carcinoma Hum pathol. 2016;41:1016- 1023.
17. Defaux AB, Dufour X, et al. Human papillomavirus (HPV) infection in head and neck region: Revue Francophone des laboratories. 2011;65-75.
18. Larson GL, Helenius G, Anerson S, Sorbe B, Karlon MG. Prognostic impact human papillomavirus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma. Gynecol oncol. 2018;129:406-11.
19. Ondzotto G, Nkoua Mbon JB, Fouemina T, Galiba J. cancer of the larynx in women: About 3 cases. Med Too. 2002;62:1717-2.
20. D’zouzaG, KreimerAR, ViscidiR et al Case control study of Human paoillomavirus and oropharyngeal cancer. N Engl J. Med. 2017;356:1944-1956.
Abstract View: 52 times
PDF Download: 28 times